It is a well-known fact that cannabis offer healing assistance too, and it has been legalized for medicinal purposes in 33 states in the USA. In this article, we will be discussing the most prevalent therapeutic uses of cannabis, one of which is the use of pain relief. Let’s get down to business and discuss some of the really interesting facts about cannabis.

Persistent Pain

The over-prescription of opioids and other addictive painkillers has directed many industrialized nations around the world, especially the USA States, to experience the epidemics of opioid overdose that sadly is constantly on the rise. Even though chronic pain management that which has an idiopathic origin, remained as the unresolved overall health dilemma, a substantial amount of medical data has exhibited that cannabis may be useful for this purpose.

In spite of the fact that the US Food and Drug Administration (FDA) has not formally declared cannabis to be an approved treatment for persistent pain, states like Colorado and The state of Michigan legalized medical cannabis have found that severe pain is the main reason for the doctor prescribed cannabis during these areas.

Chemotherapy-Induced Nausea and Throwing up

Nausea and throwing up related to radiation treatment present a problem to patients. Cannabinoids have shown some usefulness as antiemetics for cancer patients undergoing chemotherapy. Because the precise systems of action are poorly understood, experts believe the capability of cannabinoids to behave in non-serotonergic receptors, CB1 receptor, makes up for their capability to delay nausea or vomiting and vomiting in patients.

Two artificial tetrahydrocannabinol (THC) arrangements known as nabilone and dronabinol have shown some success in treating nausea or vomiting and vomiting in certain studies but not others, and improvements in symptoms have been moderate. Some of the major limitations of current THC-rich cannabinoids to treat chemotherapy induced nausea or vomiting aniting (CINV) include their bad bioavailability, delayed starting point of action and unpredictable gastrointestinal intake. Furthermore, the changed neurological states, such as disorientation, automatisierter wahn and euphoria that can often be obtained from exposure to THC, are usually unwanted side effects that limit the scientific practicality of this specific treatment option.

Neurological Circumstances

Several of the natural actions of cannabinoids, that is the term used to pertain to the total 100 biologically lively chemicals present in the marijuana plant, are mediated by way of an interaction with the 2 main cannabinoid receptors called as type 2 (CB2) and type 1 (CB1).

Within the nervous system (CNS), mutually CB2 and CB1 receptors can be found within neurons and microglia, respectively. More specifically, CB1 receptors can be found in both GABAergic interneurons and glutamatergic, both of which played a role in the inhibition of synaptic transmission.

Several fresh studies have verified the capability of cannabinoids to do something as both the non-competitive antagonist alongside CB1 receptors and also an inverse agonist with CB2 receptors, thereby showing the ability of cannabis and the chemical constituents to target these paths for therapeutic purposes.

To this end, cannabis has already been used as a possible treatment for several neurological problems including epilepsy, amyotrophic lateral sclerosis (ALS), Huntington's disease, Parkinson’s disease, dementia and traumatic brain damage, to mention a few.

The use of cannabis for the treating seizures and epileptic conditions has shown especially promising results.